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Numerous genes essential for coordinated cell proliferation including CCNA2, CCNB2 and MAD2 are downregulated during this phase, confirming that the CAM has entered a more quiescent developmental stage.
The outer integument would therefore be a good system to study the mechanisms of coordinated cell proliferation that result in the final shape of a plant organ.
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Certain dual-function regulators may serve as links for coordinating cell proliferation and differentiation.
Interestingly, there is a "compensatory mechanism" that coordinates cell proliferation and expansion during organ growth [ 27- 29].
Many signaling pathways that drive tissue growth have been found to coordinate cell proliferation and apoptosis during animal development.
The PI3K pathway activates two mTOR complexes, mTOR complex 1 (mTORC1) and mTORC2, both of which coordinate cell proliferation with nutrient availability via effects on many biosynthetic processes [ 4].
Many of the signaling pathways implicated in the normal control of tissue growth during animal development have been found to coordinate cell proliferation and apoptosis.
Although several extrinsic and intrinsic molecules regulate switching from cell proliferation to differentiation through the equator (Mochizuki and Masai, 2014), molecular mechanisms that spatially coordinate cell proliferation in the lens epithelium remain to be elucidated.
We suggest that unknown aspects of cell−cell communication coordinate cell proliferation and differentiation within the entire anther such that defects in one cell type cause organ growth arrest.
DOI: http://dx.doi.org/10.7554/eLife.07389.002 Tissue morphogenesis is a complex process, through which the organism coordinates cell proliferation and cell death with cell migration and rearrangements to achieve final organ shape and size.
TRIB2, which is an atypical protein serine-threonine kinase, is known to coordinate cell proliferation, migration, and morphogenesis during the development of Drosophila and Xenopus embryos and is involved in apoptosis in mammalian cell lines [ 39].
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