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Following introduction of DNA damage, cells elicit a complex DNA damage response comprised of coordinated cell cycle arrest, DNA repair, and in some instances apoptosis.
Surgical removal of 70% of the liver mass, in a process termed partial hepatechtomy (PH), leads to a coordinated cell cycle entry of hepatocytes in the remaining lobes resulting in the compensatory outgrowth of a full-sized functional liver.
NO was found to trigger a specific and coordinated cell cycle arrest independent of both cGMP and cAMP.
Neoplasms arising within these organisms also rely on a coordinated cell cycle to facilitate their rapid growth rate in response to external sources of nutrients and signaling stimuli.
These protozoa possess complex life cycles that involve development in mammalian and insect hosts, and a tightly coordinated cell cycle ensures propagation of the highly polarized cells.
This is consistent with the pathway analysis results reported above and suggests that ZEB1 may control the expression of genes involved in coordinated cell cycle arrest, an essential step in 3T3-L1 differenTangion (Tang et al., 2003).
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Georges, S. A. et al. Coordinated regulation of cell cycle transcripts by p53-inducible microRNAs, miR-192 and miR-215.
Regardless of the initial stimulus, proliferation is ultimately dependent upon the coordinated activation of cell cycle regulatory genes whose transcription is tightly controlled in mammalian cells.
Cellular response to DNA damage involves the coordinated activation of cell cycle checkpoints and DNA repair.
As a series of coordinated events, the cell cycle consists of distinct phases namely S, M, G1, and G2.
A subset of transcription factors responsible for the coordinated regulation of cell cycle genes has been uncovered [ 10].
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