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This cycle is coordinated by binding and breaking down a molecule called ATP, which also provides the energy needed to take the next step.
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The positioning of residues and proton transfer leading to phosphoryl transfer are coordinated by the binding of the nucleotide through its interaction with His216.
Here we show that opening and closing of the caps in the SULT1A1 dimer are allosterically coordinated by the binding of nucleotide.
This alternating cycle is coordinated by kinesin binding to and breaking down a molecule called ATP to form another molecule called ADP, which releases the energy needed for its next step.
The catalytic cycle of a sesquiterpene synthase begins with binding of the diphosphate moiety of FPP to positively charged residues and Mg2+ cofactors coordinated by two Mg2+-binding elements, the "DDxxD" motif and the "NSE/DTE" motif, both sitting at the entrance to the active site.
One explanation for this observation may be that the second-largest subunit's contribution to magnesium ion binding at the Metal B site is slightly less critical than the magnesium binding coordinated by the largest subunit.
We found that embelin docks into the active site of TACE that contains zinc atom coordinated by a conserved zinc binding motif (405-HexGHxxGxxH-415) [ 15] as shown by the analysis of three dimensional structure of TACE by Q-site Finder server.
We observed a phenomenon that these phages displayed a common motif but showed different binding ability further suggests that the motif is important for the binding while this binding ability is coordinated by flanking sequences.
In E. coli the metal binding is coordinated by four of these residues: E41 and D45 that belong to the signature box (NERLEFLGDS), and D114 and E117 [ 5].
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), existing as homotrimer in solution, contains a unique zinc-binding site coordinated by three Cys230 residues at the tip of trimeric interface.
The crystal structure of GOOX-T1 reveals a monomeric glycoprotein with a flavin adenine dinucleotide (FAD -binding domain coordinated by a bi-covalent linkage to H70 (8α-N1-histidyl) and C130 (6-S-cysteinyl); GOOX-T1 is also characterized by having a comparatively open substrate-binding site [ 14].
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CEO of Professional Science Editing for Scientists @ prosciediting.com