In C. intestinalis, this step-wise segregation of heart vs pharyngeal muscle fate is coordinated by (1) activation of Tbx1/10 in the STVCs (Wang et al., 2013) and (2) Tbx1/10-dependent activation of Collier/Olf/EBF (Ciinte.Ebf, previously named COE) in the ASMFs (Stolfi et al., 2010; Wang et al., 2013; Razy-Krajka et al., 2014).
This timing is coordinated by the activation of Env's spring-loaded fusion machinery only when the virus is attaching to an infectable cell via CD4.
The results demonstrated an enhanced proinflammatory capacity of Gr-1high monocytes marginated to the pulmonary microvasculature that is coordinated by differential activation of the p38 MApathwaypathway, indicating its central role in orchestrating monocyte-mediated pulmonary microvascular inflammation during ALI.
Skeletal myogenesis is coordinated by the activation of the myogenic regulatory factors (MRFs) in response to the upstream regulators paired domain- and homeobox-containing proteins Pax3 and Pax7 expressed in different precursor cells during development.
The physiological stress response is mainly coordinated by the hypothalamus, with activation of the ANS and the pituitary and adrenal glands (HPA axis) resulting in the release of catecholamines and cortisol, respectively [ 1, 9, 17].
The cell cycle phases are coordinated by the expression and/or activation of regulatory proteins, like cyclins (e.g., cyclin A, D, and E), cyclin-dependent kinases (Cdk) mainly Cdk-1 and -2, and Cdk inhibitors.
In addition, a sulphate ion is coordinated by Y713 and R706 in the activation segment, thereby mimicking autophosphorylation (see Figure 3B).
The regulation of cell proliferation of progenitor cells and differentiation of cell fates is coordinated by Notch homologue (NOTCH) signalling through activation of hairy and enhancer of split 1 [ 13].
Activation of Caspase-2 is coordinated by complex pre- or post-translational modifications of enzyme expression or function, respectively.
Transcriptional activation of osmotic stress response genes is coordinated by the MAP kinase Hog1 (Capaldi et al. 2008; O'Rourke and Herskowitz 2004).
