Sentence examples for coordinated alterations of from inspiring English sources

Despite our increasing understanding of the biochemical and cell biological functions of different co-chaperones, we know very little about how coordinated alterations of multiple components of the co-chaperone network could lead to dynamic adaptations of the proteostasis machinery.

Platonova, S. et al. Profound coordinated alterations of intratumoral NK cell phenotype and function in lung carcinoma.

Breast cancer is a complex disease that manifests as a result of coordinated alterations on genomic, epigenomic, and proteomic levels.

Coordinated alteration of ligand receptor pairs was successfully applied to 9-cis retinoic acid (RXR), all-trans retinoic acid (RAR), estrogen (ER), thyroid hormone (TR), vitamin D receptor (VDR) and ecdysone receptors (EcR) of the NHR family.

In conclusion, we have shown that hyperoxia induces a coordinated alteration of entire gene modules of cell junctions and attachments and a MET.

The biopsy culture caused the coordinated alteration of promoter methylation in active but not in treated disease (Supplementary Material, Fig. S2).

Meanwhile, the set of highly coexpressed genes that make up the GFD-specific response to PTG showed no correlation at all among controls, suggesting an aberrant and coordinated alteration of several genes of the NFκB route in the acute response to gliadin that is mounted in the celiac mucosa.

Interestingly, in our study, correlation of methylation levels in patients seemed to be somehow associated with the disruption of the coexpression of those same gene pairs, suggesting a coordinated alteration of gene promoter methylation of NFκB-related genes that could affect gene expression, disrupting the regulatory equilibrium of the pathway.

Recent studies of tissue-specific splicing factors are revealing how coordinated alterations in alternative splicing of RNA transcripts control synaptic function.

Reductions in cell division have been associated with coordinated alterations in the expression of some key cell-cycle genes [ 44, 47].

In comparison with cultured procyclic and bloodstream forms, there were increases in mRNAs encoding the stumpy-form markers ESAG9 and PIP39, with coordinated alterations in the levels of over 600 additional mRNAs.