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With new IT technologies, the organization can coordinate up and down the hierarchy more quickly and with more detail.
We could show, that MT1 has the ability to coordinate up to five Zn2+ or Cd2+ ions and even higher amounts of Hg2+.
HMS2, encoding a growth-regulated transcription factor, switches between sense- or antisense-dominant states that also coordinate up- and down-regulation of transcription at neighbouring genes.
However, it does not appear to hold true generally, since we observed independent expression of the members of a number of other pairs (e.g., bg10 in submaxillary and sublingual glands; a10 in VNO and MOE, etc).. Thus, regulation of the expressions of Abpa and Abpbg members of pairs must be more complex than simple coordinate up- or down-regulation of pairs.
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This could reflect coordinate up-regulation of the overall phenylpropanoid pathway in response to increased anthocyanin biosynthesis.
IPA network analysis revealed coordinate up-regulation of several DKK1 transcriptional regulators (TCF4, EZH2, DNAJB6 and HDAC2) in cisplatin-surviving clones from that biological replicate.
There is no transcriptional evidence to suggest that this coordinate up-regulation of lipogenesis in myoblasts, normally considered an insulin response, is modulated by the hierarchical SREBPs.
Suppose that we are interested in gene sets with coordinate up-regulated differential expression (the CES formulas for the other events of interest can be derived similarly).
We therefore sought to determine whether this coordinate up-regulation of fatty acid and cholesterol biosynthetic genes in myoblasts, normally ascribed to as an insulin response, was modulated by the hierarchical lipogenic sterol regulatory element binding proteins (SREBPs).
ASK1 phosphorylates JNK in response to stress, resulting in activation of c-Jun and stimulation of apoptosis [ 47], indicating that the coordinate up-regulation of RAF1 and down-regulation of JUN may provide a potent anti-apoptotic effect in BT.siMUC1.
RNA-seq data revealed that the coordinate up-regulation of MHC-I processing pathways and down-regulation of MHC-II-associated pathways occurred at the early stage of vaccine immunization, providing insights into the molecular mechanisms of immune protection.
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