Exact(4)
Now that the complete human genome sequence is available [ 1], the current challenges are to identify all the functional genetic elements it encodes and to elucidate the complex regulatory networks that coordinate the function of all genetic and epigenetic elements that are crucial for cellular homeostasis, development and disease progression [ 2, 3].
This is important because it suggests that gene epigenetic interactions should be considered in the context of a multilevel and bidirectional landscape, with other epigenetic regulators also acting to coordinate the function of the genome in a cell- and context-specific manner.
Through this dimensionless coordinate, the function N can be written as N^{2}=x A x), (59) where (A x)>0) for (0leq xleq1).
The BAG-1 ULD is required for the interaction of BAG-1 with the proteasome (Luders et al, 2000a), and substantial evidence shows that BAG-1 can act to coordinate the function of chaperones and the proteasome in the degradation of specific proteins (Arndt et al, 2007).
Similar(56)
Thus, the primary functional purpose of consciousness is to integrate, provide access, and coordinate the functioning of very large numbers of specialized networks that otherwise operate autonomously.
"I have ordered the security minister to take actions and special steps to coordinate the functions of all the security forces to overcome the crisis," Mr. Wahid said in a statement.
However, this study suggests that subcellular localization may also be a fairly frequent event for other transcription factor transcripts, providing a unique way to temporally and spatially coordinate the functions of otherwise independently regulated genes (Lecuyer et al. 2009).
Considering that hBora interacts with both Aurora A and Plk1 but is itself controlled by Plk1, it follows that hBora could contribute to coordinate the functions of these two key regulators of mitotic progression.
The dual function of basonuclin to regulate two groups of genes, (i.e., Pol I- and Pol II-transcribed) suggests that it coordinates the function of these genes.
An example of a cis-acting regulatory activity that coordinates the function of multiple promoters in complex gene loci is that supported by the promoter targeting sequence (PTS) [43].
Nuclear transcription controls mitochondrial function, ultimately coordinating the function and capacity of the organelle in response to intrinsic and extrinsic signals.
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