Previous reports have shown Th1-like effector memory cells to be increased in bronchoalveolar cells from TST+ individuals as compared with TST− individuals, with coordinate increase in IFNγ and IFNγ regulated chemokines [36].
Instead, a majority of these genes including Sulf1 (GeneID: 240725), Mmp11 (GeneID: 17385), Timp3 (GeneID: 21859), Adam22 (GeneID: 11496), Adamts20 (GeneID: 223838), and Adamtsl1 (GeneID: 77739) showed a coordinate increase in expression in the three prominences (Figure 14B).
The coordinate increase in CCL2 and TNFα responses observed in the pulmonary TB group, may indicate active monocyte recruitment to the lungs which are likely to facilitate granuloma formation and localization of M. tuberculosis infection.
In addition, a coordinate increase in the anti-apoptotic protein Bcl-2 was seen following estrogen treatment.
A coordinate increase in the content of proteins involved in carbohydrate metabolism and energy generation as well as in general and oxidative stress response was registered.
Both cell migration and adhesion are key markers of an inflammatory response, therefore differential activation of CD148 in inflammatory cells and a coordinate increase in endogenous ligand(s) could lead to an enhancement of the inflammatory response in migratory cells.
In addition to repressing the expression of several collagen transcripts, we also found that FoxO was necessary for the coordinate increase in the gene expression of matrix metalloproteinase 8 (Mmp8) and Mmp9 in muscles of cachectic tumor-bearing mice (Table 2 and Additional file 3: Table S1), which participate in the degradation of Type I, II and III collagens and Type IV collagens, respectively.
We report for the first time a coordinate increase in expression of acidic keratins perhaps indicating a partial mesenchymal to epithelial (epidermal) transition (MET), a decrease in insulin/IGF-1 signaling with lower phosphor-Akt, and decreased expression of anti-oxidant-related genes that suggests lower metabolism and growth compared with aerobic culture.
We observed coordinated increases in the expression levels of these four genes in the brain of the schizophrenic subjects.
By simply altering facX expression levels in a given cellular framework, we could simulate the generation of a new OC and SCD, which coordinated increase in size when facX is further upregulated (see Fig. S5 and Text S5).
