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Beyond its potential to provide control over the reaction coordinate, force is also an important physiological parameter that affects protein conformation under in vivo conditions.
While it is well-known that the structural scaffold that exists between myocytes in the heart is composed of extracellular matrix (matrix) and mesenchymal cells and that this matrix provides an exceptionally strong means to tether and coordinate force generated via myocyte contraction, little is known of their regulation.
The final computational model of Stat1 SH2 in a complex with each compound was determined by local minimization using Internal Coordinate Force Field (ICFF -based molecular mechanICFF -based
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Through interactions with the talin-integrin complex and the actin cytoskeleton [ 11 13], vinculin is ideally positioned to coordinate force-induced signals.
Controlling these disorders, in turn, restores coordinated force generation to avoid sudden cardiac death.
In this study, we test the hypothesis that vinculin coordinates force-mediated signals.
He called for the creation of retail retention zones to protect small businesses threatened by national chains, with incentives offered to landlords in return for low rents; a moratorium on the rezoning of 1,800 acres of manufacturing space, to promote the expansion of existing companies; and the creation of a new mayoral office to coordinate work force development programs throughout the city.
In this study a reverse system identification approach is presented that utilizes generalized coordinate and force functions to recover the value of the key system parameters for each mode of vibration.
Regular army units that joined the rebellion have proven stronger and more organized, but only a few units have joined the battles while many have stayed behind as officers try to coordinate a force with often antiquated, limited equipment.
Nurses are front-line practitioners, known for spending the most time with patients and also being the main coordinating force for all other medical practitioners [ 12].
A US-style National Crime Agency will have a sweeping new power to step in to directly task and coordinate police forces in a bid to tackle organised crime and secure the UK's borders, the Home Secretary said.
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