Overall, the coordinate effects of Rab25 mutation on AKT binding and ATP levels, glycogen content and glucose uptake suggests that the ability of Rab25 to bind and regulate AKT plays a critical role in the ability of Rab25 to regulate cellular bioenergetics, a contention supported by the PI3K, AKT and GSK3 inhibitor studies.
Every agent has an individual representation of the environment, and they are related through the coordinating effect of communication between agents with partial autonomy.
More complicated phenomena can be represented as the combined or coordinated effects of gain and loss of function.
Uniquely, GLP-1R agonists exert coordinated effects on mechanisms of glucose release and nutrient uptake, suppress inappropriately elevated glucagon secretion, slow gastric emptying, and increase satiety with the net result of reduced body weight [ 2].
Stigmergy is a means of interaction between agents and is used to coordinate the effect of current actions to stimulate further actions.
The present study utilizes fundamental fluid relations which normally only vary with the area ratio; however, through the reintroduction of the axial coordinate, the effect of the nozzle contour on the pressure profile can be evaluated.
One way to coordinate the effects of CXCL12 signaling in the various CXCR4-expressing cell types is to exploit tissue-specific intracellular signaling pathways.
In addition to extending our knowledge of the role of EIN3 in coordinating the effects of ethylene, the work of Chang et al. reveals the extensive connectivity between pathways regulated by distinct hormones in plants.
Analysis of Variance of the Discriminant Analysis of Principal Component (DAPC) coordinates reveal the effect of use type, population type, sowing type and geographical origins.
In this work, by comparison of the topological characteristics and biological functions between module hubs and inter-module hubs, we speculate that inter-module hubs are more likely to play important roles in response to external signal stimulation and in coordinating the joint effect of many modules.
