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These factors coordinate acquisition of the mesenchymal phenotype through (1) downregulation of epithelial cadherin (E-Cad) involved in maintenance of cell polarity, (2) induction of intermediate filament proteins such as vimentin, (3) activation of small GTPases (to induce motility), and (4) expression of matrix metalloproteinases (MMPs) and collagen to induce fibrogenesis.
Coordinate acquisition was done for the various parts using a Coordinate Measuring Machine (CMM).
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Later in the evening, the White House issued a statement saying Mr. Bush and Mr. Blair had agreed to establish procedures to allow their two governments to better share sensitive information and to establish a bilateral committee to better coordinate defense acquisition activities.
When IMT is required, 54.5 % (CI = 0.46 0.63) of respondents would coordinate IMT acquisition with specialists such as rheumatologists, dermatologists, or general internists.
When IMTs are required, 5.5 % of physicians (8/145; 1 no response; CI = 0.02 0.11) would prescribe the IMT themselves, while 54.5%% (79/145; CI = 0.46 0.63) would seek prescription of the IMT from a rheumatologist, dermatologist, or general internist, and 40.0 % (58/145; CI = 0.32 0.48) would refer to an ophthalmologist to coordinate the acquisition of IMT.
MS, BP, TS participated in the study design, helped to coordinate data acquisition, made substantial contributions to interpretation of the data and critically revised the manuscript.
NVD participated in the design and coordination of the study, coordinated the acquisition of patient data and clinical samples, and revised the manuscript.
TM and JOC coordinated the acquisition of laboratory samples, clinical data acquisition, and entry of clinical and laboratory variables into the database.
Given the limitations of timely access to uveitis specialists, coordinating the acquisition of IMT with other specialists such as rheumatologists and internists is essential.
FN coordinated data acquisition.
JE coordinated sample acquisition.
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