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By working cooperatively or sequentially, these E3 ligases appear to target activated signaling complexes in anergic T cells and disrupt the nascent immunological synapse and inhibit the ongoing TCR signaling cascade.
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Indeed, the alpha catalytic subunit of PP1, PP1 α, was shown to act cooperatively and sequentially with (Ca2+ -calmodulin-protein phosphatase 2B (PP2B) in UV irradiated or hexamethylene bisaCa2+ -calmodulin-proteinCa2+ -calmodulin-protein released from 7SK snRNphosphatase 66].
The workers can either invest simultaneously or sequentially with the favorite being the first mover or sequentially with the underdog as first mover.
The analysis can even become very complex if different tests are combined or sequentially used.
Sometimes the same product will show up under many different names at the same time or sequentially.
Daily vaccinations are implemented either simultaneously or sequentially, similar to the imposition of travel restrictions.
Two wavelength channels (495 and 590 nm) were recorded simultaneously or sequentially.
Pexophagy as other autophagic processes proceeds via a multistep pathway, controlled by about 30 genes, acting cooperatively and sequentially in autophagosome formation, vesicle fusion and vacuolar degradation [ 65, 66].
Is it better to target behaviors concurrently or sequentially?
No patients showed hypertriglyceridemia with propofol used alone or sequentially.
Remainders received either trastuzumab or lapatinib and trastuzumab (either concomitantly or sequentially) with or without chemotherapy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com