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We also show that specific and nonspecific TF-DNA binding are functionally linked and cooperatively influence gene expression in yeast.
The dependence of HAP morphology on phosphate concentration suggests that, in biomineralisation, biological genetic and physicochemical factors can cooperatively influence the formation of hydroxyapatite with unusual morphologies and hierarchical structures.
Importantly, we are the first demonstrating a pathway where RANTES and S100A4 cooperatively influence cell migration.
To determine whether these results reflect deficiencies in prosurvival signaling, we examined whether KLF4/5 could cooperatively influence cell death following matrix deprivation (anoikis).
Another important avenue to explore is whether other factors cooperatively influence lipogenesis in myoblasts together with the SREBPs, following induction by IGF-1.
Taken together with these reports, our findings suggest that LAT1 and phosphorylated S6 ribosomal protein (Ser-235/236) may cooperatively influence the invasive potential and progression of RCC.
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However, Model 2 is still incomplete as it does not capture the reverse or symmetrical cooperative dependence, when one Ca2+ binding site cooperatively influences another, and another site can in the same way influence the first site, within both terminals.
However, the C- terminal exhibited much higher affinity for a cooperatively influenced binding site (for a Ca2+ binding site when the neighbouring site is occupied).
Most recently, mismatch signals have been shown in the primary cortex of the mouse to be cooperatively influenced by motor-related input (Keller et al. 2012).
A comparison of the model predictions with the Ca2+-CaM-parts of skMLCK and CaATPase peptide binding data suggests that both the K1 and the cooperatively influenced K2 dissociation constants are different when peptides are bound to CaM species with less than 3 Ca2+ ions or to CaM species with 3 or 4 ions.
In this case, we will define the dissociation constants as K1, K2, K 2 c o o p, K3, K4, K 4 c o o p, where K 2 c o o p and K 4 c o o p are the cooperatively influenced dissociation constants for the second and fourth centres when the ligand is bound to the first and third binding sites, correspondingly.
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