Recent work from Taguchi et al. [ 35] illustrated that EPLIN and vinculin may collaborate together in AJ formation via binding α-catenin either together or individually and cooperatively aid junctional adhesion [ 35].
As a route to addressing this, we link the methods of thermodynamic integration (TI) and swarm-enhanced sampling molecular dynamics (sesMD), where simulation replicas interact cooperatively to aid transitions over energy barriers.
The two partners were likely to be expressed reciprocally and function cooperatively [ 41], which aided our further investigation of the function of nested gene pair.
In addition, they provide evidence that comparisons of nondisruptive fission sites in homologous proteins could be useful for finding dynamic regions whose conformational fluctuations are important for function, and they show that the discovery of protein fragments that cooperatively function in mesophiles can be aided by the use of thermophilic enzymes as starting points for protein design.
To study the effect of CycE overexpression in proliferation of bristle lineage in Drosophila, Simon et al. (2009) have shown that Notch acts as a repressor, whereas in Scrib mutants, Notch aids cooperatively in cell proliferation and survival with the Scrib gene (Brumby and Richardson 2003).
The results described herein show how combining random gene fission with fusion to ORFs encoding associating proteins can aid the discovery of protein fragments that cooperatively function (fluorescence) and display two-input AND gate logic (two-promoter regulation).
Thus, combined, these results show, for the first time, that Nupr1 aids oncogenic Kras to bypass senescence in a manner that cooperatively promotes PanIN formation.
In other words, play against a player much better than you in a competitive game, and you'll likely not have a lot of fun, as he'll be killing you over and over again, but play with the same player cooperatively, and he suddenly becomes this heroic character, able to help you through the most difficult of firefights and come to your aid when you've overstretched yourself.
He cooperatively made an introductory call.
