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That is the year the first Veterans Administration Cooperative Trial was published, which confirmed that treatment of patients with high blood pressure resulted in fewer strokes, deaths and cardiovascular complications.
The Veterans Affairs cooperative trial [ 24] and the San Francisco Emergency Medical Services study [ 25] both found IV lorazepam provided the best termination rates for SE.
Hematologists were invited to complete the online questionnaire "Treatment of the elderly with a hematologic malignancy" on behalf of the Dutch-Belgian Cooperative Trial Group for Hemato-Oncology (HOVON).
Their trials and outcomes are described below and summarized in Figure 1 and Table 2. Several US pediatric cooperative trial groups merged in the year 2000 to form the COG.
Whereas one-third of panelists considered surveillance the preferred treatment strategy in all stage I seminoma regardless of the risk factors for relapse, others opted for surveillance in 'low-risk' patients with a relapse rate of 5%12%%, and adjuvant treatment in 'high-risk' patients as had been pursued in the Spanish cooperative trial [ 19].
Almost all centers treating childhood cancer belong to large cooperative trial groups, and previous research has shown that a majority of cancer patients less that 15 years of age are registered in clinical trials across virtually all metropolitan and rural areas across the United States [ 28, 29].
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This National Cancer Institute supported clinical cooperative trials group based in Pittsburgh, PA, currently has 200 member institutions and 700 satellite centers located throughout the United States, Canada, Puerto Rico, and Ireland.
Data from this investigation support the use of FISH as an adjunct method to increase the yield of useful cytogenetic results in large cooperative trials and demonstrate the potential of FISH as a follow-up study of minimal residual disease in ECOG trials.
Indeed the incidence of cooperative trials, R and S, was lower than that of defective trials (Friedman's ANOVA testing for effect of outcome, Q(3) = 43.135, two-tailed P<0.0001, Figure 4b and Figure S2 for individual performances).
The potential to use this information must be tested in larger, prospective, cooperative trials.
If different centers agreed to include assessment of core domains with a standard set of measures, the design and conduct of such cooperative trials would be facilitated.
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