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We will then develop a method for the reengineering of meso-scale structures for non-hierarchical networks, which allow to model cooperative interaction on a homogeneous level of the system structure, for example, phosphorylation of signalling proteins in response to external stimuli and inhibition.
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Upon viral infection, activation of the gene encoding IFN-β critically depends on cooperative interaction of the DNA-binding domains of ATF-2/c-Jun and the immune regulatory factor (IRF -3 [21].
The global carbon cycle and the production of a number of biofuels depends on the cooperative interaction of a physiological diversity of anaerobic microorganisms.
Experimental evidence suggests that at least in some cases, however, there should be a high degree of sensitivity to reflect the important protein-protein cooperative interactions on enhancers [ 29- 31].
Controlled motion in supramolecular systems must be built on cooperative interactions of individually weak but collectively strong noncovalent interactions.
The observed effects can be explained on the basis of and steric and electronic effects and cooperative interactions of the two adjacent metal centers in dinuclear complexes.
Another advantage is that it provides flexibility, as new CV terms can be defined to describe additional features of cooperative interactions, for instance, based on the classification scheme for allosteric mechanisms that has been defined previously (81) or information captured in the AlloSteric Database (ASD) (82).
Evolution of weak cooperative interactions for biological specificity.
Ant algorithm which is based on the cooperative interaction between artificial ants has proved to be an effective tool for such designing.
Furthermore, the ability of YY1 to activate Nkx2.5 expression depends on its cooperative interaction with Gata4 at a nearby chromatin.
The data suggest that in vivo fitness of the domain III chimeric virus is dependent on a cooperative interaction between the 5'NTR, 3'NTR and NS5A at a step in the viral life cycle subsequent to genome replication, most likely during particle assembly.
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