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BACKGROUND: This phase II cooperative group study of patients with unresectable stage III non small-cell lunon small-celldesigned to treat patients with induction chemotherapy with paclungxel and cancerlatin (PC) followas by concurrent chemotherapy with the same chemotherapy plus thoracic irradesignedto 66 Gy.
The present multicenter cooperative group study was developed to improve these situations.
This cooperative group study of 262 women has been reported in abstract form and no benefit was observed [ 83].
The CHTN is not involved in obtaining tissue removed solely for research purposes; where this is an expectation in a cooperative group study, specific informed consent must be obtained.
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To review the history of nurse involvement within the cooperative group environment, define the role of the nurse liaison, identify challenges for the nurse in interdisciplinary research, and explore future trends of nurse involvement in cooperative group studies.
Some study findings were published only in abstracts and others were from cooperative group studies.
CIRB pass-throughs, mostly from the NCI's cooperative group studies, have helped streamline our work.
Cooperative group studies have been suggested to address design limitations and increase statistical power (33).
Large, cooperative group studies are needed to address these design limitations.
One report of young adults enrolled in cooperative group studies shows an inferior outcome for young adults due to increased distant relapse.
A cooperative group multicenter study by PETHEMA (LPA2005) administered cytarabine only in high-risk patients, achieving a lower CIR at 3 years (11% vs 26%, P=0.03) compared with historical controls from LPA99 trial.
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