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Interestingly, for CTCF and to a small extent Zfx, the cooperative model outperformed the non-cooperative one, even though no significant cooperative factor was found, suggesting that self-cooperativity may play a role in these factors.
We show that subtle perturbations to these properties can transform an individual sTF between distinct roles (activator, cooperative factor, inhibitory factor) within a transcriptional complex, thus drastically altering the signal processing behavior of multi-input systems.
From Table S4, we chose the most significant cooperative factor, as defined by p values, for each primary TF (removing those not showing large improvements in the testing data).
We note that when there are more than one cooperative factor, we do not allow interactions among these factors, as doing so will greatly increase the number of parameters (quadratic to the number of factors), and we may not be able to estimate them since we only have binding data for the primary factor.
The palindrome might as well function as a cooperative factor binding site.
Repeating of the motif is typically associated with a cooperative factor binding.
Similar(54)
MyoD binding can be modified by both cooperative factors and inhibitors, including microRNAs that may serve as important developmental switches.
The above trade-off study of all the cooperative factors that affected the electrochemical property might make an effective guidance for preparation of promising FeOx/CNF anodes.
Supplementary stability tests were performed on i-PP containing four stabiliser couples (triazine+HALS) and the cooperative factors resulting from the synergistic activities of oxidation prevention couple were determined.
Furthermore, master regulators including transcription factors are also promising target to be engineered because stress tolerance is determined by many cooperative factors and modification of master regulators can simultaneously affect the expression of multiple downstream genes.
After all cooperative factors are learned, and STAP re-trains the model parameters.
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