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The activation energy of about 222 kJ/mol indicates that the transition occurred via cooperative disruption of several hydrogen bonds.
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For example, do these networks act as fully cooperative units where disruption of any connection would dissipate the advantage from all of the residues in the network?
Our data suggest that both proteolytic activity as well as ECM deposition are necessary for cooperative invasion because disruption of either completely abrogates invasion in heterogeneous xenografts.
Inversely, the fitness loss associated with the disruption of cooperative behavior of pathogens may facilitate therapy [39], e.g., by weakening their invasive potential.
Indeed, our research here together with this previous study suggests that a positive feedback loop between JNK activation and Myosin II activity might be critical downstream of cell morphology or polarity disruption for cooperative tumorigenesis with oncogenic Ras.
Comparing the total expression across samples of interest can reveal disruptions in cooperative function.
This phenomenon may be attributed to the disruption of a cooperative physical cross-linking (i.e. the hydrogen bonding and the ionic cross-linking) on the networks, which was proved by the change of FT-IR spectra of hydrogels during swelling.
Notably, introducing Sytl1 was sufficient to induce AML in Hoxa9-expressing cells; conversely, its disruption abolished the cooperative function of Meis1 in engraftment.
Therefore, disruption of the cooperative interplay resulting from partial down-regulation of MyD88 signaling in B cells and kidney cells would act to break the persistent cycle of inflammation and vascular permeability resulting in kidney damage in SLE without fully immunosuppressing the host.
The loss of correlation between SOPT and VCALT moving from healthy controls to patients may infer that a structural and/or functional disruption of the normally cooperative action between the networks involved should also exist in schizophrenia spectrum disorders.
Within tumors, disruption of these core processes, through cooperative oncogenic lesions, results in aggressive, metastatic disease.
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