Sentence examples for cooperative changes in from inspiring English sources
The cooperative changes in the modulus and two structure parameters — the misorientation angle and the paracrystalline parameter upon treatment — indicate a direct structure property correlation.
However, for large protein families these regions predict quite well coordinated or cooperative changes in proteins.
Under milder conditions, cooperative changes in the tertiary and secondary structure conformations can still affect ligand functionality [ 24].
The F876L mutation allows for cooperative changes in neighboring residues which, when bound to enzalutamide, enable H12 to adopt a more agonist-like conformation.
Interestingly, none of the IL-4Rα variants showed a strong cooperative change in binding affinity for the IL-4 super-agonist T13D and F82D when compared to wild-type IL-4, suggesting that the additional interactions between T13D-F82D and IL-4Rα are not formed directly between Asp13 or Asp82 and any of the IL-4Rα side chains investigated here.
They are involved in changing of partners, but also in changing of different residues, cooperative changes can even lead to the adoption of new functions.
l-LDHs generally have tetrameric structures comprising four identical subunits, and allosteric l-LDHs undergo cooperative structural changes in the substrate and FBP binding sites through quaternary structural changes (Iwata et al. [1994]; Arai et al. [2010]).
In any case, it is noteworthy that cofilin clusters induced distinctly asymmetric cooperative conformational changes in neighboring bare zones.
Thank you for sending your work entitled "Cofilin-induced unidirectional cooperative conformational changes in actin filaments revealed by high-speed AFM" for consideration at eLife.
More recently, a systems biology approach was used by Bredel et al. [ 12] to describe a network model of cooperative genetic changes in gliomas and, most importantly, to evaluate its clinical relevance in terms of patient survival.
A related question is how many bound cofilin molecules are required to induce cooperative supertwisting conformational changes in actin filaments?
