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Thus, activation of Wnt signalling in this case is cooperating to drive either MAPK or PI3 kinase pathway activation depending on the cooperating mutation.
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Mr. Ahmadinejad later called for Iraq, Iran and Turkey to cooperate to drive Kurdish guerrillas from the Iraqi border areas they use to stage attacks into both countries.
Our studies provide evidence for four protein modules that cooperate to drive coat formation, membrane invagination, actin-meshwork assembly, and vesicle scission during clathrin/actin-mediated endocytosis.
Mouse studies indicate that either is sufficient for melanoma predisposition and that they might, in fact, cooperate to drive disease progression [76] [77].
The combined loss of both IL-6 and IL-21 almost completely abrogated early virus-specific antibody production, indicating that both cytokines cooperate to drive plasma cell responses (Figure 4).
Then, Aurora-A/STK15 ectopic upregulation and inactivation of p53 tumour suppressor pathway could cooperate to drive initial centrosome amplification and aneuploidy in HCT116 cells.
In this issue, the results by Cabeen et al argue for one attractive mechanism whereby these elements cooperate to drive cellular morphogenesis.
Our results reveal how BMP4 and FGF2 (via ERK) cooperate to drive efficient hESC differentiation into early mesodermal cells, which characteristically express high levels of BRA.
Activation of the MAPK and NF-κB pathways cooperate to drive the gene expression of proinflammatory cytokines such as IL-1β, IL-6, IL-8, and TNFα.
In summary, we have functionally the tested the ability of Ras and Wnt pathway to cooperate to drive bladder carcinogenesis and find that they robustly cooperate to promote non-metastatic bladder tumours.
Altogether, our data indicate that the PROX promoter is responsible for miR-206 expression in growth conditions, whereas upon differentiation, both PROX and DIST cooperate to drive transcription of the locus.
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