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Importantly, our observations with HQ are highly consistent with observations in human patients and in mice showing that heterozygous Nf1 inactivation cooperates strongly with genotoxins (particularly radiation) to induce myeloid malignancies and other secondary cancers [ 17, 19].
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On the LCD TV markets, Sony and Samsung cooperated strongly in R&D and manufacturing while commercializing innovative flat screen TVs.
Although Pou5f1, Sox2, and Nanog cooperate strongly in their effects on target genes, their roles may not be equal.
Activated Rho proteins cooperate strongly with oncogenes Ras and Raf in focus-formation assays, but either fail to independently induce transformation or else exhibit weak transforming activity [ 6- 9].
"The two intelligence agencies on both sides must cooperate more strongly, if we are to deal with terrorists and extremists more effectively," he said.
He suggests his diplomacy allowed the two countries to cooperate more strongly to stop asylum seekers arriving by boat to Australia.
Austria's Social Democrat prime minister, Werner Faymann, who faced calls to resign after the vote, said the result was a "clear signal to the government that we have to cooperate more strongly".
Taken together these data definitively show Ras pathway activation strongly cooperates with Wnt signalling to drive UCC in vivo.
In this study, we show that deregulation of Wnt signalling strongly cooperates with the activation of Ras to drive tumourigenesis.
We have previously shown that activation of the Wnt signalling pathway in the bladder of mice alone fails to drive UCC, however, it strongly cooperates with PTEN loss to drive tumourigenesis.
On the whole, the hERG1 gene can be considered a "tumor progression" gene, as it strongly cooperates with genetic (loss of the tumor-suppressor gene Apc) or environmental (chemical carcinogen) factors in triggering CRC progression.
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