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CVD: Cardiovascular disease; HD: Hemodialysis; PD: Peritoneal dialysis; CCSD: China cooperate study on dialysis.
However, the COOPERATE study was retracted and in the ONTARGET clinical trial dual blockade was more effective in decreasing albuminuria but increased the risk of adverse renal outcomes [ 3, 4].
The COOPERATE study 48 even showed that dual therapy with trandolapril and losartan reduced the risk of the primary endpoint (time to doubling of serum creatinine level or end stage renal disease) by 60% better than monotherapy, thereby becoming one of the most widely quoted studies by the Lancet.
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We wish to thank all the participants of the DIANA study and our cooperating study partners.
Inclusion criteria were age < 80 years, a weight of 50 120 kg, and an ability to provide informed consent for the study and to cooperate with study personnel.
We included only patients who had been fully able to understand and cooperate with study procedures.
Patients were excluded if they were unable to give informed consent or were unable to understand or cooperate with study conditions.
We included patients aged 65 and over with diabetes type 2 diagnosed minimum 1 year earlier, subjects who had been able to understand and cooperate with study procedures.
Subjects were excluded if any other form of arthritis was present, if there was any contraindication tomagnetic resonance imaging (MRI), if a total knee replacement was planned, or if they were unable to cooperate with study requirements.
The parent or guardian had to be able cooperate with study requirements (ability to speak, read and write English, have a telephone at home and not expected to move within the next month).
The Soviets and Americans would cooperate in studying the ecology, archeology and cultural heritage of both sides of the strait, once the site of a land bridge linking North America and Asia.
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