Sentence examples for cooperate in the induction of from inspiring English sources
We have previously shown that S1P in combination with LPS cooperate in the induction of proinflammatory cytokines and the inhibition of Sphk-1 did not affect the induction of proinflammatory cytokines in HGECs [65].
Our results are consistent with the notion that Smad3 and Ets-1 cooperate in the induction of the CCN2 promoter by TGFβ1.
Indeed, TGF-β1 and oncogenic Ras cooperate in the induction of Snail1 expression and EMT in epithelial cells (Peinado et al, 2003).
Consistent with these observations, Bim and Fas-deficiencies also cooperate in the induction of autoimmunity very early in age, accompanied by massive accumulation of leukocytes that can make up to half of the animal's body mass.
Moreover, they demonstrated that Raf and TGFβ also cooperate in the induction of E-cadherin monoubiquitination; this effect is explained by TGFβ-dependent transcriptional induction of the E3 ubiquitin ligase Hakai and the Raf-dependent tyrosine phosphorylation of E-cadherin.
MMTV-induced murine models of cancer have been extremely useful, not only in discovering oncogenes that promote mammary cancer, but also for identifying oncogenes that cooperate in the induction of the tumours.
In hepatocyte cells, TGF- β also stimulates Bim transcription by upregulating Runx1 expression, which binds FOXO3a, and the two factors cooperate in the transcriptional induction of Bim.
Additionally, obatoclax is shown to cooperate with the induction of Bim as a synthetic lethal partner to drive cell death.
Both in cancer and fibrosis TGF-β1, TNF-α and hypoxia cooperate in the triggering of EMT, converging in the induction of Snail activity through different mechanisms among which the activation of NF-κB seems to play a central role.
While further studies are required to determine whether this particular mechanism also applies to other T cell lineages, it appears that IL-6 and IL-1 cooperate not only in the induction of Th17 differentiation but also in the generation of a Th1 response.
In this study, we provide evidence that oncogenic KRAS facilitates chemotherapy-induced apoptosis of HCT116 colorectal tumour cells by cooperating with p53 in the induction of the pro-apoptotic gene Noxa.
