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Recently it was reported that a small group of genes, regulated by HIF-2 rather than HIF-1, have at least one HRE in proximity to an ETS transcription factor-binding site (EBS) and that HIF-2 α and ETS-family member physically interact and cooperate in regulation of these genes (Aprelikova et al, 2006).
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The studies revealed that orexins cooperate also in regulation of blood pressure and heart rate and release of some hypothalamic hormones [ 18].
The EAF2−/−VHL+/− mouse model demonstrates that these two tumor suppressors cooperate in the regulation of angiogenesis and that loss of these genes contributes to the development of neoplasia in the liver and prostate.
We therefore examined the lung genes regulated by Nfib and Nr3c1 and the specific binding targets of NFIB to determine how these genes may cooperate in the regulation of lung maturation.
This demonstrates that PP2A B55α and importin-β1 cooperate in the regulation of postmitotic assembly mechanisms in human cells.
Previous studies have shown that p53 and NF-kappaB can cooperate in the regulation of gene expression, however, with conflicting results.
Additionally, many cis-elements co-localize in the long upstream sequences and cooperate in the regulation of gene transcription (Carrera and Treisman 2008).
The enrichment of E-boxes further indicates that the circadian clock and the light response are closely intertwined and cooperate in the regulation of many light induced genes.
Indeed, previous studies have reported that AP-1 and PU.1 can cooperate in the regulation of cellular genes in macrophages [48], such as for the adipose differentiation-related protein gene [51].
In triploblastic animals, Runx and CBFβ proteins are known to cooperate in the regulation of gene expression by binding DNA as heterodimers (see [ 51] and references therein).
It has been well established that DNA methylation and histone modifications cross-talk and cooperate in the regulation of gene transcription.
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