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To date, four genes identified using candidate gene association studies have been convincingly associated with type 2 diabetes: A proline-to-alanine change in codon 12 (P12A) of the peroxisome proliferator activated receptor γ (PPARG) gene was the first genetic variant to be definitively implicated in the common form of type 2 diabetes (9, 10).
In this model only ACA+ and high levels of IL-6 remained convincingly associated with plaque occurrence, while the association with diastolic blood pressure was of borderline significance (Table 5).
Although a SNP (rs4963128) in PHRF1 (previously known as KIAA1542) has been convincingly associated with SLE [ 85, 86], and this association is believed to be due to linkage disequilibrium (LD) with IRF7, no study has yet directly tested IRF7.
However, no SNPs were identified from this analysis that were convincingly associated with atorvastatin-mediated lipid changes (P>1×10−7 for all associations) [13].
The lack of association with CIMT measurements suggests that these novel SNPs, while convincingly associated with CAD risk, do not influence development of carotid atherosclerosis.
A recent genome-wide association study (GWAS) found two SNPs, rs2115763 and rs1834481, independently and convincingly associated with IL-18 levels 18.
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However, many studies in the following years failed to convincingly associate ATM with breast cancer [ 199– 20199
Although scientific evidence convincingly associates dietary content to health effects, we know that food decision-making is a complex process and involves more than taking into account the nutritive value of the foods.
Though ArfA was found by proteomic analysis on phagosomes [42] and on magnetically purified endosomes (our unpublished work), no ArfAGFP staining was convincingly seen associated with the phagosomes or macropinosomes (Figure 7D), possibly due to transient interactions.
Although the MHC2TA -168A>G polymorphism has convincingly been associated with MHC2TA gene expression, it is unclear whether the polymorphism itself is functional or whether it is in linkage disequilibrium with one or more causal genetic variants.
Taken together, these data suggest that diabetes may be an early indicator of pancreatic cancer in some patients; however, diabetes and its related biomarkers are convincingly also associated with the etiology of pancreatic cancer.
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