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Small sample sizes may have led to inconsistent results in early studies, but in the past few years, there has been growing and convincing support for the transferability of the FTO locus across almost all ancestries that have been studied.
Overall, these results offer no convincing support for the initial hypotheses, so further research must be pursued to explain the individual variation in MFD severity.
Although, the inclusion of SNPs in our study was based on potential functional role in genes with higher potential of being associated to cancer risk, a more comprehensive approach including tagging SNPs would present more convincing support for the associations.
Studies of endogenous proteins/loss-of-function analysis are needed to provide more convincing support for the authors' conclusions.
Collectively, these studies provided convincing support for the importance of core clock genes in regulating sleep behavior.
These observations offer a convincing support for the function of AtPP2-A1 in conferring the plant resistance shown as a repression in phloem-feeding activity of the insect.
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Although it is now acknowledged that this high diversity is most probably a simple consequence of a large population size, convincing support for this explanation would require a rigorous assessment of the silent nucleotide diversity in natural populations of marine bivalves, which has not yet been done.
Finally, the analysis of plant ESTs failed to convincing support for major multiple populations of alternatively spliced transcripts for the 25 dicot and 26 monocot LKR/SDH exons (exceptions being the monofunctional transcripts described above).
Only in the nucleomorph SSU rDNA tree, however, convincing support for clade LB was found.
We appreciate the authors' review of this topic and find from their analysis convincing support for expanding LTBI treatment guidelines.
Conversely, two recent analyses based on mixed markers and 62 nuclear genes found, convincing support for Mandibulata (Bourlat et al. 2008, Regier et al. 2010).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com