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However, we did not see convincing improvements in patient-reported diabetes symptoms, diabetes distress, depression, or other clinical (e.g., blood pressure) or laboratory (e.g., lipid) values.
Numerous chemotherapy-based strategies, including dose intensification, weekly administration, 3- or 4-drug regimens, high-dose consolidation, alternating or sequential non-cross-resistant regimens, and maintenance therapy, have failed to yield convincing improvements in survival, and several of these approaches have resulted in unacceptable toxicity.
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Current treatments for ATC are aggressive - including surgery, radiation therapy and chemotherapy – but no study has shown a convincing improvement in survival [3], perhaps because they do not adequately target the cancer-initiating cells.
However published clinical studies showing convincing improvement in therapeutic ratio are not yet available.
Most of the studies that investigated self-efficacy showed convincing improvement in self-efficacy, cognitive symptom-management and mental stress-management.
Today, it is widely accepted that the low performance level of surgically implanted port catheters represents one major reason why the theoretical advantage of 5-FU-based HAI could not be transferred to convincing clinical improvements so far.
The ATAC trial showed a convincing early improvement in disease-free survival for the anastrozole arm, a finding which generated great interest and led to the rapid and widespread changes in practice described above.
Attack coach Rob Howley, who will take the reins again for the forthcoming Six Nations with Gatland resuming Lions duties full-time, took heart from the performance of the back three, centre Jonathan Davies and fly-half Rhys Priestland, who without being entirely convincing, showed an improvement in his kicking game and an ability to spark the Welsh attack.
We found no convincing evidence of improvement in the reporting of CAM during the study period, but a controlled parallel intervention, or formal time series analysis of a more active feedback program would be needed in order to draw any confident conclusions about the potential for improvement.
14 16 Despite marked improvement in ICP and headache, we found no convincing signs of overall cognitive improvement at the 3-month follow-up as the improvement seen in the visuospatial tests could be explained by the test retest effect (familiarisation with the Rey-Osterrieth complex figure).
The most convincing evidence of health improvement came from two studies in New Zealand.
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