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Until now no convincing benefit of IGF-I pathway inhibitors was found in clinical studies in BC [ 38– 40].
Using 'any improvement' as a measure of efficacy, no consistent and convincing benefit of pregabalin over placebo was apparent.
In summary, no convincing benefit of surgery has been shown for proximal humeral fractures, despite several attempts involving many hundreds of patients in randomized trials.
Although no convincing benefit for Src inhibitors as single agents in patients with refractory metastatic colorectal cancer has thus far been reported from early-phase trials [ 17], preclinical studies have shown that the combination of the Src inhibitor dasatinib with oxaliplatin significantly reduced the volume of hepatic metastases in mice relative to treatment with either agent alone [ 18].
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Sunitinib, pazopanib, and bevacizumab plus interferon have demonstrated convincing clinical benefit in patients with favorable or intermediate prognosis [ 13– 19, 27].
Convincing cost-benefit analyses of the schemes are still missing.
When the right hormone preparations are thoughtfully applied in the right women for the right reasons, I am convinced considerable benefit can come of it.
Inability to deal with the issues of "connection" and, in particular, failing to convince on benefits and immigration.
High community awareness of cervical cancer symptoms is encouraging; women may thus recognize cervical cancer by its symptoms and might seek treatment early if they are convinced of benefits of available care at the hospitals.
Moreover, MMB even enlisted banks to boost sales by convincing them about the benefits of the transgenic technology and, thus, the benefits of providing credit to the farmers.
Convincing Poles of the benefits of adopting the euro would be a hard political sell for Mr. Tusk, but should that stop him from trying?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com