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Potentially, the localization of the aggregates could shed light on the toxic mechanism, by identifying the organelle where Ure2 conveys its effect.
The protein environment conveys its effect via several routes.
14 What could be the mechanism by which SRP9 conveys its effect on FS susceptibility?
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PNS conveys its effects by the electrical stimulation of peripheral nerves branches either sub- or percutaneously with implantable devices, or transcutaneously via superficial skin electrodes linked to external neurostimulators.
Our findings identify SRP9 as a novel FS susceptibility gene and indicate that SRP9 conveys its effects through endoplasmic reticulum (ER -dependent synthER -dependentficking of membrane proteinsynthesiss glutandtraffickings.
42 Srp9 appears to convey its effect on FS susceptibility through ER-dependent protein synthesis and trafficking, resulting in altered expression of cell membrane proteins, such as glutamate receptor subunits.
Over-expressed Mdm2 protein conveys its inhibitory effect by binding directly to p53 either to inhibit its transcriptional activity or to target it to proteasomal degradation.
This has led to the suggestion that l-deprenyl conveys its protective effects via the activation of antiapoptosis pathways within the cell, and that this neuroprotection is independent of MAO-B inhibition.
The Shabab is ready to deploy suicide-bombers at home and abroad to further its cause.Where it has control, it conveys its message with ruthless effect.
As for clinical translation, rosiglitazone, a widely used anti-diabetic agent was shown to convey its anti-tumour effects via the induction of MKP-1.
Woolcock does at least recognise that the sea is as much the main protagonist here as it is in Peter Grimes and she and her visual team have devised some strikingly beautiful stage effects to convey its omnipresence.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com