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Previous association studies also suggest that serogroup HLA-A10 may convey a protective effect [46].
However, this is proving to be an immensely complex task because it is difficult to predict which immunological response(s) in candidate vaccine-challenged animals or in vitro studies will convey a protective effect in humans [1], [2], [3].
These survival curves also underscore two other points: First, a HLA-B*57-containing genotype does not require the presence of a 'protective' HLA-C allele to convey a protective effect on disease progression.
Folate depletion appears to enhance carcinogenesis, whereas folate supplementation may convey a protective effect (Kim, 1999).
A history of hypertension was found to convey a protective effect (OR = 0.62, 95% CI = 0.52 to 0.73).
Hendershot and colleagues (2010) tested an intervention that targeted the ALDH2 genotype, found almost exclusively in individuals of northeast Asian descent, which can convey a protective effect against alcohol misuse.
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A history of hypertension conveying a protective effect was an unexpected result on multivariate analysis.
Recent studies have isolated the farm, rather than the general rural environment as the factor conveying a protective effect against atopy.
Similarly, Kondrashova et al. reported lower celiac disease prevalence in a Russian area than in a bordering area of Finland, suggesting that the lower socioeconomic status and/or inferior hygienic standard in Russia conveyed a protective effect against celiac disease [ 29].
This would convey a spurious protective effect of ephedrine/caffeine; cases were less likely to use ephedrine/caffeine on their case date than on their control date, since they were approximately 1 year older and possibly had entered a period of lower ephedrine/caffeine use in general.
Taken together, these data infer that Tanshinone IIA therapy conveys a direct protective effect on renal tubules.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com