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Rho GTPase-activating proteins (GAPs) inactivate them by converting the active GTP-bound state to the inactive GDP-bound one through activation of the intrinsic GTPase activity of Rho proteins.
In addition the active carbon gasification reaction was not observed for the Cu-containing catalyst converting the active carbon in a very convenient support for the WGS reaction.
Molecular modeling and dynamics simulation of DmTDO-heme-Trp suggest that like prokaryotic TDOs, DmTDO adopts an induced-fit mechanism to bind l-Trp; in particular, two conserved but flexible loops undergo conformational changes, converting the active site from an open conformation to a closed conformation.
The dose range for the phase 1 trial was chosen to bracket the most active portion (trough) of the U, converting the active dose range from mouse to man using well-established rules of interspecies dose conversion (Freireich et al, 1966).
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Allosteric regulators are known to affect caspase enzyme activity, in general, by facilitating large conformational changes that convert the active enzyme to a zymogen-like form in which the substrate-binding pocket is disordered.
These traces are converted by multi-hit TDCs, which only convert the active channels and thus reduce the processing load.
D3 converts the active hormone T3 to inactive metabolites thereby terminating TH action within cells.
Hsbp1 is a nuclear-localized protein that converts the active trimeric state of Heat shock factor 1 (Hsf1) to the inert monomeric state.
The nondimensional scaling parameter a′ (Equation 56) which converts the active transport velocities into forces acting on the cytoplasmic fluid absorbs several unknown quantities including the size of the cargo that drives fluid flow, drag forces on the fluid with local viscosity, the density of such cargo motor complexes on MTs and any collective effects.
It converts the active metabolite of IRI, SN38, to its inactive glucuronide (Iyer et al, 1998) and is expressed in the liver, the relative amount being dependent on the number of TA-repeats in the promoter of the gene (wild-type, TA6 or UGT1A1*28, TA7).
Plasmin is one of the major enzymes responsible for converting the proMMPs into their active form.
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