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Is the capacity of human ductal cells to be converted toward endocrine islet fates unique?
In a mouse model of rheumatoid arthritis, Foxp3 fate reporter mice revealed that "exFoxp3+" cells converted toward Th17 cells under IL-6 exposure in the synovia and became highly osteoclastogenic [ 44].
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Thus, ITS copies can potentially convert toward one or the other parent, and the resulting sequence homogeneity can obscure a history of contributions from multiple distinct donors.
Moreover, Th17 cells were shown to convert toward TFH phenotype in Peyer's patches.
However, whether Th17 cells actually convert toward Treg phenotype in vivo in a tumor microenvironment is still unknown.
Accordingly, using fate reporter mice, the same team has further recently shown that Th17 cells could convert toward a TR1 phenotype.
Whether Th17 cells will convert toward Th1 cells locally within the tumor or whether Th17/Th1 hybrid cells will be recruited within the tumor is unknown.
While Th17 cells seem to easily convert toward a Th1 phenotype, Th1 cells are considered stable and mostly refractory to conversion toward Th17 cells or other Th subsets, suggesting that plasticity between Th1 and Th17 cells is rather asymmetric.
Treg cells extracted from psoriatic patient blood revealed higher susceptibility to convert toward Th17 cells than Treg cells from the blood of healthy donors, and Foxp3+ IL-17+ cellscells were detected in psoriatic lesions [ 43].
All together these results show that M1-like GFP+ macrophages expressing high levels of tnfa first accumulate at the wound 6hpA and then convert toward a M2-like GFP+ macrophage phenotype in situ 26hpA.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com