Though it is known that triphosphates are relatively unstable, this study for the first time showed triphosphates could be converted sequentially to monophosphates or even nucleosides during the heating process.
Capecitabine is absorbed as an intact molecule from the small bowel mucosa and converted sequentially to 5-FU in a multistep enzymatic process (Bollag and Hartmann, 1980; Hartmann and Bollag, 1980).
A conversion of G6P into fructose-1,6-bisphosphate (FBP) follows, which is then converted sequentially to glyceraldehyde-3-phosphate (Ga3P), 3-phosphoglyceric acid (3-PGA) and PEP [ 16].
a, The first step is to work out a theoretical pathway by which a target molecule is sequentially converted into intermediates that can be easily prepared or purchased.
To determine whether all seven RNA nucleosides were required for Cas9 activity, each nucleoside in turn was sequentially converted to DNA and assessed for in vitro cleavage activity (Fig. 2a).
To identify an orally available fluoropyrimidine having efficacy and safety profiles greatly improved over those of parenteral 5-fluorouracil (5-FU: 1), we designed a 5-FU prodrug that would pass intact through the intestinal mucisa and be sequentially converted to 5-FU by enzymes that are highly expressed in the human liver and then in tumors.
Then, through a three-step chain reaction, water is sequentially converted into a number of radicals and molecular products: hydrated electrons (( {e}_{aq}^Big) ), hydrogen atom( H∙), hydroxyl radical OH·, hydroperoxyl radical (( {HO}_2^Big) ), hydrogen peroxide (H2O2), and hydrogen molecules (H2) [5, 6].
Specifically, the reconstruction shows that F. succinogenes contains both a phosphoenolpyruvate carboxykinase (Fisuc_2949) and a pyruvate carboxylase (Fisuc_0845) that can reversibly convert PEP and pyruvate, respectively, to oxaloacetate, which is sequentially converted to malate, fumarate, and succinate.
Once incorporated into the cell, cellodextrins can be sequentially converted to glucose-1-phosphate by the action of cellodextrin phosphorlyase, whose presence has been demonstrated in cell-free extracts.
Aspartate semialdehyde is then sequentially converted into homoserine, phosphohomoserine, and threonine.
Intracellular LTC4 is actively transported extracellularly, where it is enzymatically sequentially converted to LTD4 and then to LTE4 [ 1].
