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The study adds to growing evidence that certain cell types can be transformed directly into other cell types without first being converted into stem cells.
These were then converted into stem cells.
Forest mensuration data consisting of tree height, DBH, and tree form, were converted into stem lists and imported into GeoMaster (forest activity planning and management software: Atlas [2012]).
The possibility to reprogram somatic cells into iPS cells, closely resembling embryonic stem cells, raised great hopes for a customized cell therapy approach, using autologous somatic cells converted into stem cells.
Human primary fibroblasts could be converted into stem cells by the same or a slightly different set of genes, such as OCT4, SOX2, NANOG (XM_002344645), and LIN28 (NM_024674).
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The exceptional plasticity of normal somatic cells, exemplified by the ability of glial progenitors [57], and the ability of mature glial cells [58], [59] to be converted into stem-like cells in response to defined environmental conditions could suggest that brain cancer cells can acquire properties of progenitor cells or of stem cells in response to permissive environmental pressure.
The main aim of this study was to delineate the potential influence of Wnt/β-catenin signaling on the survival of the total population of ISPCs in response to DNA damage rather than to re-investigate the discrimination of intestinal stem and progenitor cells and the plasticity of early progenitors to convert into stem cells or vice versa.
"It can be destroyed, it can be implanted into a woman or it can be converted into embryonic stem cells.
Mouse embryonic fibroblasts have been converted into pluripotent stem cells (iPSC) in vitro, by expressing four genes, SOX2 (NM_003106), OCT4 (NM_002701), KLF4 (NM_004235), and C-MYC (NM_002467) or, alternatively, N-MYC (NM_005378).
With the technological advances demonstrating that human fibroblasts can be converted into pluripotent stem (iPS) cells and subsequently into neurons, and the promise of this technology to provide new cellular models of human neurodegenerative disease, it was only a matter of time for this technology to be applied to the study of AD.
A major limitation to the use of agents with CSC-specific toxicity is the possibility for the non-stem cells to convert into cancer stem cells.
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