One notable exception, though, is Rocketplane's entry, the XP, which is an extensively converted Learjet.At first sight, the notion of converting an executive jet into a spaceship might seem rather dangerous.
After oral administration, the prodrug was readily absorbed and extensively converted to tenofovir.
Protocatechuic aldehyde was extensively converted into protocatechuic acid and other metabolites.
After oral administration, adefovir dipivoxil is readily absorbed from the gastrointestinal tract and extensively converted to adefovir.
However, in actual humans, bupropion is extensively converted in the body into several active metabolites with differing activity and influence on the effects of bupropion during first-pass metabolism.
Oseltamivir is extensively converted to its active metabolite by the esterases present in the liver, whereas the anti-inflammatory drugs rolipram and sertraline have been shown to undergo phase I metabolism utilizing cytochrome P450.
Following oral administration, ESL is rapidly and extensively converted to the major active metabolite, (S -licarbazepine (eS -licarbazepinevia hydrolytic first-pass meslicarbazepine consequently, ESL is undetectable in plasma as early as 15 min postdose.
Amodiaquine is also considered to be a prodrug and is rapidly and extensively converted to its main metabolite, N-desethylamodiaquine (DEAQ), essentially in the liver by cytochrome P 2C8 (CYP2C8) [ 9].
Artesunate [dihydroartemisinin-10α-hemisuccinate, molecular weight (MW) 384] is considered to be a prodrug, as it is rapidly and extensively converted via chemical and enzymatic pathways to its main bioactive metabolite, dihydroartemisinin (DHA; also referred to as artenimol, MW 284).
