Sentence examples for conversion of glutamine from inspiring English sources
In addition, oncogenic Myc increases glutamine uptake and the conversion of glutamine into a mitochondrial carbon source by promoting the expression of GLS [54].
A two-step microbial process for the conversion of glutamine from tuna condensate to gamma-aminobutyric acid (GABA) via glutamic acid was developed.
Additionally, Gao et al. demonstrated that MYC controls the conversion of glutamine to glutamate by activating glutaminase 1 (GLS1) through transcriptional suppression of its negative regulator miR-23a/b (Wise et al., 2008; Gao et al., 2009).
CB-839 disrupts the conversion of glutamine to glutamate and alters a number of downstream pathways, including the TCA cycle, glutathione production, and amino acid synthesis (Gross et al., 2010; Jacque et al., 2015).
Thus, for example, studies on C13 NMR spectroscopy have demonstrated that glutaminolysis constitutes an active metabolic pathway in human glioblastoma cell lines [8], and consequently, a demand reaction of α-ketoglutarate representing an intermediary compound along the conversion of glutamine to lactate was included in the reconstruction.
Glutaminolysis is defined as the conversion of glutamine to glutamate.
Encephalopathy has been related to the "glutamine hypothesis" wherein detoxification of ammonia by astrocytes leads to conversion of glutamate to glutamine, which can increase tissue osmolarity and cause oedema [54], [55].
Examples include cytidine triphosphate synthase (Noree et al., 2010), an enzyme involved in the synthesis of cytosine nucleotides, and glutamine synthetase (Narayanaswamy et al., 2009), an enzyme that promotes the conversion of glutamate into glutamine.
This ammonia must eventually be disposed of which likely occurs predominantly by conversion of glutamate to glutamine by GS.
Astrocytic uptake of glutamate and the conversion of glutamate to glutamine is the predominant mechanism of inactivation of glutamate once released in the synaptic cleft.
GS has a very high affinity for ammonia and catalyzes the ATP-dependent conversion of glutamate into glutamine by incorporating a molecule of ammonia.
