As the information on whether such mutations are coincident between both alleles is not clear, I wonder whether the authors can exclude the possibility that such high levels could be due to gene conversion type of events whether or not mediated by double-strand breaks.
The detection of three gene conversion events from about 153 Alu Ye elements suggests that gene conversion of these events has been relatively rare, with a rate of 1.96%.
I can't think of a better metaphor for the private-to-public conversion of the events of September 11th.
No animals have been harmed and no one has cried (although the announcement of Sachin Tendulkar's retirement upset some greatly).The conversion of future events to present experiences continues, however, as The World in 2014 will show from this coming Monday.
The Rivet system provides all of the analysis tools required to project a Monte Carlo weight upon an observable bin, and the MCgrid package provides the correct conversion of the event weight to an APPLgrid fill call.
Since the time scale in the measured data was shifted for the sake of synchronization of the conversion events of Rab5 and Rab7 domain proteins, we rescaled it in order to conduct a direct comparison of the numeric simulation (reference model) with the measured data: We used the transformation t ← 4 t + 850.
This proposed mechanism was confirmed by analysis of the types of conversion events stimulated by γ-rays in synchronized G1 and G2 cells (Lee and Petes 2010).
While in some species, almost the entire gene sequences have undergone concerted evolution, others had a mosaic pattern of conversion events, where some segments of the genes are homogenized and evolved in concert, while others diverged without gene conversion [ 27].
2) When trying to fit models of tract length and GC rate, it is important to include not just the observed number of conversion events, but also the distribution of the number of SNPs co-converted.
Accurate detection of conversion events can contribute substantially to other studies of gene cluster evolution by correcting duplication ages distorted by conversion and by improving the identification of orthology relationships in complex gene clusters.
