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Conversely, gain of a biomarker could offer the possibility to adopt new therapies but this event is relatively rare.
Conversely, gain of chromosome 19 in glioblastoma has been correlated with a poor prognosis [ 10], an effect attributed to radiation resistance [ 11].
Conversely, gain of expression of N-cadherin is frequently observed in carcinomas and its forced expression promotes motility and metastasis of prostate and breast cancer cells.
Based on the findings of Lee et al (2009), we expected MKRN1-depleted ESCs to harbor a heightened tolerance for genotoxic stress, and conversely gain of MKRN1 function to sensitize ESCs to ADR-induced apoptosis.
Conversely, gain of FGF23 function by injection of wild-type mice with recombinant FGF23 or by elevated circulating levels of endogenous Fgf23 in Hyp mice increases distal tubular Na+ uptake and membrane abundance of NCC, leading to volume expansion, hypertension, and heart hypertrophy in a αKlotho and dietary Na+-dependent fashion.
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Conversely, gain-of-function of these regulators triggers cell cycle arrest and cell death.
Conversely, gain-of-function (GOF) experiments with JAG2 (GOF-JAG2) resulted in the decrease in MN differentiation and the percentage of Islet1+/BrdU− decreased to 33±0.02% (∼1.5-fold decrease; Figures 2e and f).
Conversely, gain-of-function studies in MCF10A cells, which were chosen for their low levels of Zeb1, indicated that ectopic Zeb1 repressed expression of miR203 and increased ΔNp63 α levels.
Conversely, gaining >12.7 kg was associated with decreased odds of spontaneous preterm birth with PROM in underweight women compared to normal weight women.
Conversely, chr7 gain without focal amplification of either EGFR or MET was most common in the NF1 transcriptomal cocluster (60.7% vs 23%, p = 1.6e−6), and this was concordant with aCGH profiling of tumors in the NF1 signaling class.
Conversely, the gain of SIRT1 function improves glucose homeostasis and insulin-sensitivity in diabetic mice models (Banks et al., 2008; Li et al., 2011).
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