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Anti-VEGFR2 acts conversely, enhancing ceramide generation and apoptosis.
Conversely, enhancing TLR2-mediated host defense may hasten clearance of SE bacteremia; consistent with protection against bacteremia afforded by hypermorphic alleles of TIRAP, a signaling molecule downstream of TLR2 [46].
Conversely, enhancing the loading and function of the IFC macrophages could improve the early humoral response to gp120 vaccines and other antigens captured by the IFC cells.
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Increases in Zn external concentration, in the presence of a steady amount of Cd, did not produced significant changes in the amount of Cd ions in the mobile fractions but conversely enhanced the amount of free Zn ions in the same fractions.
When the free Ca2+ concentration was elevated to 150 nM or 28 µM, the activities of gBK channels were conversely enhanced by 100 nM martentoxin.
Indeed, sorafenib cotreatment distinctly increased intracellular KP1339 levels, and KP1339 conversely enhanced sorafenib accumulation.
Conversely, enhanced PYK2 signaling facilitates cell survival in an anchorage-independent manner [ 7], and promotes cell motility [ 8].
This observation is in line with other studies that have shown enhanced Stat3 expression and activation in Stat1 null cells [ 16] and, conversely, enhanced Stat1 expression and activation in Stat-3 null cells [ 17].
Conversely, enhanced glucose transport achieved by overabundance of GLUT4 results in increased UCP production and activity in skeletal muscle, which in turn raises glucose use and lowers blood glucose [ 30].
Conversely, enhanced GABABR-GIRK signaling seen in a mouse model of Down syndrome disrupts both excitatory and inhibitory synaptic plasticity, and is linked to cognitive impairment (Kleschevnikov et al., 2004; Cramer et al., 2010; Cooper et al., 2012).
We found that PGE2 generation and cell proliferation were reduced by mPGES-1 knockdown and conversely enhanced by mPGES-1 overexpression in LLC cells (a PGE2-dependent mouse lung carcinoma cell line; [ 27]), indicating the role of mPGES-1, acting downstream of COX-2, in providing the mitogenic PGE2.
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