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Conversely, differentiated tumor cells, incapable of long-term self-renewal but representing the majority of the cells within hematologic and solid cancers, are not tumorigenic.
Conversely, differentiated cells showed high responsivity with maximal cell viability reduction (−80% vs. untreated cells) observed after 48 h, and a mean IC50 of 0.38 μM.
Conversely, differentiated bMSC expressed lower (P < 0.05) mRNA levels of NANOG at 96 h and 144 h of culture (16.3- and 17.4-fold relative to Day 0 vs. 47.9- and 25.8-fold in untreated controls).
Conversely, differentiated neuronal nuclei (Neu-N) were not detected (Figure 2-D) confirming that the neuronal precursors present in the neurospheres are at the immature state.
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Conversely, the differentiated spermatogonia (Kit+ α6+SP) contain about 60% of Dr5+ cells, with a 30% increase post IR.
Conversely, fully differentiated 3T3-L1 adipocytes with knockdown of endogenous SRA had decreased insulin-stimulated glucose uptake (Figure 5C) and decreased phosphorylation of Akt and FOXO1 (Figure 5D).
Conversely, slightly differentiated chlorophyllic structures were clearly perceived after three months culture on the same medium.
Conversely, poorly differentiated (grade III) ESCC samples showed relatively low galectin-7 expression.
In particular, most low-grade tumors that displayed features of luminal A, conversely poorly differentiated were mainly luminal B and HER2 positive nonluminal subtypes (P = 0.000).
Conversely, for the differentiated cell line IMR90, transcription data (CAGE) is a much better predictor of chromatin interaction preferences than sequence-derived features.
Conversely, in a differentiated state, Zeb1 expression is repressed resulting in increased miR203 levels, suppression of ΔNp63 α and increased expression of HBP1.
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