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Two one-sided test statistics may be formed: one for testing higher frequencies in cases than controls (risk variants) and one for the converse test of higher frequencies in controls than cases (protective variants).
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The converse, a biosimilar tested in the metastatic setting extrapolated to early breast cancer, would not be acceptable.
In a converse experiment, we tested the effect of over-expression of a dFz2 + transgene on flight deficits induced by pan-neuronal knockdown of the IP3R (itpr-IR), dSTIM (dSTIM-IR) and dOrai (dOrai-IR) and observed a significant rescue in all three conditions tested.
To test the converse interaction, PP1 was affinity purified from MEF lysates using microcystin agarose beads.
Accordingly, we aimed to test the converse situation by reducing membrane egress from the recycling compartment by overexpressing RAB11 (Ren et al., 1998) or by inhibiting Myosin Vb by overexpressing its tail domain (Lapierre et al., 2001).
We next tested the converse effect of suppressing SPRED2 using siRNA knockdown in PC3M cells.
PPARγ can promote adipogenesis in C/EBPα-deficient cells, but the converse has not been tested [ 5].
Perhaps most strikingly, Disc1 transgenic mice, an animal model of schizophrenia-related phenotypes, display both reduced PV interneurons in the frontal cortex and increased immobility in depression-related tests, the converse of the responses we found in the D2R nulls.
Simultaneously, we tested the converse hypothesis that higher general intelligence aids in learning to read controlling for earlier reading ability by assessing the significance of the paths marked C in Figure 1.
In the experimental group, students who had scored well on the conceptual evaluation after instruction were also likely to score well on the achievement test and the converse was also true.
Begin to test the waters and converse with women you find attractive.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com