Unlike ethopropazine, converse site-directed mutagenesis of the acyl pocket has not been reported for BChE and iso-OMPA.
For all species, the region has the features of a CpG island (CPGPlot), and contains conversed SP1 binding site sequences.
These days, when she is not conversing through her Web site, jancisrobinson.com, or writing a wine column for The Financial Times, she is either working on the next edition of "The Oxford Companion" or the equally crucial reference "World Atlas of Wine," which was handed off to her by Mr. Johnson.
The converse (exposure of conserved sites) apparently occurs in a smaller number of cases, indicating a different evolutionary adaptive strategy in these plants.
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Here, we present evidence that the converse is true, with binding site plasticity of STAT transcription factors representing an ancestral state.
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"Molly" met a man on an online dating site and they conversed regularly for about a month before the man told Molly that his daughter needed heart surgery.
Initial sequence alignments were obtained using MAFFT [88], [89] and optimized by eyes using the conserved cysteine residues, the conserved W-X-X-W motif and conversed RXXR proconvertase enzyme cleavage site.
Sequence-based methods explore the sequence conservation in proteins under the assumption that ligand-binding site sequences are conversed in the evolution process.
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