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In summary, the study findings are based on converging effects from a number of methodological approaches.
The other 28 exhibit harmonized physiologic behavior regarding diabetes and atherosclerosis; each one presents converging effects on both diseases.
Without urgent and concerted action, the converging effects of climate change, abject poverty, and violent extremism at play in the Sahel risk spiraling out of control.
The winter run on the ruble was triggered by the converging effects of sanctions and the nadir in oil prices that flirted with $45 a barrel in December.
Anxiety seems to be central to the converging effects of antidepressant treatment and BLA lesions.
The converging effects of stress on the dynorphin kappa opioid system in the BLA and its key role in mediating the adverse effects of stress implies that new therapeutic strategies should be directed toward the development of KOR antagonists.
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This model combines the high predictive value of explant cultures with quick, sensitive, and quantifiable readout converging the effects via various pathways including WNT-signaling, to SP7/osterix promoter activity.
The major finding of our work is that the overall anti-fibrotic activity of PI by bortezomib results from two distinct but functionally converging regulatory effects summarized in Figure 7. On one hand, we have documented that enhanced transcription of the MMP-1 gene depends on enhanced binding of c-Jun to the most proximal AP-1 binding site of the MMP-1 promoter.
This involves direct receptor-mediated effects and paracrine effects converging at the RANKL/OPG level.
Overall, these data suggest that by targeting different, yet converging, pathways, additive effects on the repair of SCI can be achieved.
It is hypothesized that by increasing the triangular effect on a texture shape, the converging micro-wedge effect is expected to increase, hence increasing the film pressure and reducing the friction.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com