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We have shown that conventional alignment procedures, which shift the global center of mass to the origin, may not produce physically plausible motions in other cross-sections.
Finally, the PCAIN methodology provides for utilizing the fold-conserved residues as "anchors" in the target-template sequence alignment step, thus increasing efficacy of conventional alignment protocols.
As conventional alignment and phylogenetic procedures of full-length sequences fell short of elucidating the evolutionary history of these genes, we started to analyze the PDZ and LIM domain sequences themselves.
Kinematic alignment was recently introduced as an alternative to conventional alignment techniques.
The conventional alignment algorithms cannot use these sequences, and they are in general not considered for analysis.
Without a decoding step, in which color data are converted to sequence data, they cannot be mapped to a reference genome using conventional alignment tools.
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Second, he felt a sense of pride in defying conventional alignments in the middle of the cold war: "I could prove myself to myself by succeeding as a known communist..
These approaches are not only much faster than conventional alignment-based methods, but they also overcome some notorious difficulties in phylogenomics, such as finding ortholog genes (Ebersberger et al., 2009; Schreiber et al., 2009) or aligning large genomic sequences (Darling et al., 2010).
In contrast to conventional methods, the signature method utilizes information present in the sequences that may not be analyzable with conventional alignments, such as additional sequences at the beginning or the end of alignments.
Two reconstruction methods were applied to the simulated sequences: the signature method, using 4, 5 and 6-letter words and the Euclidian and the χ2 metrics, and the distance method using conventional alignments.
In contrast to most comparative multi-sequence alignment tools (reviewed by [ 7]), which display columns of sequences that contain gaps to optimize alignments, the species-centric EvoPrint is a single uninterrupted sequence and thus displays more bases in a single view than is possible with conventional alignments.
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