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Algorithms should be developed to extend these treatments in the most convenient phase of the disorder, allowing also better combination with conventional therapies.
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Following the development of solid-phase synthesis that generated a series of libraries of aminosteroid derivatives, we now report the development of a convenient liquid phase chemical synthesis of RM-133, the most promising candidate, in order to obtain sufficient quantities to proceed with the first preclinical assays.
Oleic acid stabilized monodisperse Fe3O4 nanoparticles were prepared by a convenient organic phase process and underwent a ligand exchange process with 2-bromo-2-methylpropionic acid (Br-MPA) to generate macroinitiator (Fe3O4@Br-MPA) for ATRP of 2-hydroxyethyl methacrylate (HEMA) to produce Fe3O4@poly 2-hydroxyethyl methacrylate) (Fe3O4@poly 2-hydroxyethyl
The LC/MS experiments revealed that ascorbic acid is a convenient mobile phase additive.
The methods were also applied to a convenient solid-phase synthesis of RNG.
A conformationally constrained peptidomimetic derived from the endocrine and neuroactive tripeptide thyrotropin-releasing hormone (pGlu-His-Pro-NH2) was synthesized by convenient solid-phase organic chemistry and evaluated as a potential central nervous system agent.
A general and convenient solid-phase synthesis method using Cu(i -mediated alkyne–azi -mediatedhemistry for alkyne azidef an azide derivative of a fluoresclicklabel to an alkyne derivative of a peptide chemistryd to a morpholino oligonucleotide (PMO).
This structural property is very convenient for the phase models and processing used in this work.
A convenient measure of phase-locking can then be generated by estimating for each time point the phase difference between oscillations at a particular frequency recorded in two separate locations and calculating the absolute value of the mean of these phase differences considered as complex numbers with unit modulus.
They are particularly convenient for two-phase small scale devices enabling solvent extraction operations.
The compounds were efficiently synthesized using a highly convenient submonomer solid-phase methodology which potentially allows for access to great product diversity.
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