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The aim of developing oral fluorouracil (5-FU) is to provide a more convenient administration route with similar efficacy and the best achievable tolerance.
These hydrogels have been interesting for biomedical uses as they can swell in situ under physiological conditions and provide the advantage of convenient administration.
SC formulations of anti-CD20 mAbs appear to be the next step in development, which could reduce IRRs, eliminate the need for premedication with glucocorticoids, and offer a potentially more convenient administration method.
Phase 1 and 2 clinical studies with PPX showed encouraging outcomes compared to standard taxanes with reduced neutropenia and alopecia and allowed a more convenient administration schedule without the need for routine premedications.
Capecitabine in combination with MMC is an effective regimen for metastatic colorectal cancer resistant to 5FU and irinotecan with an acceptable toxicity profile and a convenient administration schedule.
A more convenient administration schedule/route, enhanced long-term efficacy and safety profiles, cost-effectiveness, and tolerability, are among the desirable characteristics that future agents must fulfill.
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The aim of this study was to investigate the toxicity and efficacy of a more convenient topotecan administration schedule (in contrast to the "standard" 1.5 mg/m2/day × 5 days q 21 days) in the management of platinum- and paclitaxel-refractory ovarian cancer.
These offer potential advantages, including simplification of treatment regimens, more convenient drug administration and reduced healthcare costs [ 5, 9, 10].
Coformulation with rHuPH20 may enable effective, well-tolerated, cost-effective, and convenient SC administration of rituximab and trastuzumab.
UFT has the advantage of convenient oral administration and a very good tolerability profile, with no hand-foot syndrome.
Capecitabine has the advantages of convenient oral administration and of mimicking the effect of protracted intravenous (i.v).v
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