Effective drug delivery to the deeper ocular tissues remains an unresolved conundrum mainly due to the expression of multidrug resistance efflux proteins, besides tight junction proteins, in the blood ocular barriers (BOBs).
As Saturday evening came I gave my conundrum due consideration and went to see Orbital.
The dengue virus presents a particular conundrum to vaccine development due to the safety concerns associated with the potential increase in the rate or severity of dengue disease by an incomplete immune response associated with poorly protective or low neutralizing antibody levels against the four serotypes (Halstead, 1988).
Non-Mendelian patterns of transmission of epigenetic silencing of genes associated with colon cancer (e.g. MLH1), can create a conundrum for genetic counseling due to the observation that epimutation of the promoter of this gene may vary from one generation to the next (Hitchins 2010).
To date, the marriage between pattern and process based methods has yet to produce cohesive and practical joint theories, largely due to the conundrum in process-to-pattern projection (not simply 1-to-1; rather, could often be 1-to-many and many-to-1).
This conundrum, in our opinion, is largely due to the fact that the genetics evaluation is still predominantly phenotype-oriented.
We and others [ 4, 16– 18] have addressed this evolutionary conundrum with the fundamental assumption that due to the Darwinian dynamics that govern somatic evolution, every common phenotype observed in cancer populations must confer an adaptive advantage.
Despite critical reception, Kaleidoscope Superior would remain the band's only commercial release; they were soon dropped from Sparrow's lineup due to "creative differences and marketing conundrums".
Reverse Transcription-Polymerase Chain Reaction (RT-PCR) analysis was performed to test whether the apparent conundrum in the transfection results between 2.7hPLPΔ3173 5806 (ninefold) and 2.7hPLPΔ3874 5810 (onefold) in Figure 5 may be due to alternative splicing.
Due to her dedication, and about halfway through the film, Sany loses her job quite the conundrum given that she and her crew are working on the film pro bono.
