"conundrum about" is correct and usable in written English.
It can be used to indicate a problem or puzzling situation that is being discussed or considered. Here is an example: "The debate over climate change continues to be a conundrum about the balance between economic growth and environmental protection."
It is the old conundrum about risk versus benefits.
But this points to a conundrum about how and whether we interpret negative behavior directed at a specific person.
An enduring conundrum about visiting wineries: they all start to look the same after the second day.
But this points to a conundrum about how and whether we interpret negative behavior directed at unique minority individuals.
But more than that, their work generates an interesting new conundrum about the nature of shaken fur dynamics.
Ford's gravity-defying political career evokes Gramsci's conundrum about the popularity of Mussolini among Italy's working class and poor.
One of the quadrennial conundrums about New Hampshire's first-in-the-nation presidential primaries is how independents will vote.
On a more personal level, the works of Philip K. Dick (often adapted for film) present metaphysical conundrums about identity, humanity, and the nature of reality.
Paul-Ryan Carberry's hyper-active Touchstone has a tendency to gabble his conundrums about mustard and pancakes and so forth, which is preferable to listening to someone trying to make sense of them.
This theory could help solve some deep scientific conundrums about our own universe (such as the so-called fine-tuning problem), but at considerable cost: Namely, the additional universes of the multiverse would lie beyond our powers of observation and could never be directly investigated.
As for "The Matrix," well, that's a whole different syllabus, since Neo, in his fetching leather trench coat, must karate-kick his way through a series of ancient philosophical conundrums about the nature of free will, the ontological status of reality and the metaphysical endowments of Italian actresses.
