Sentence examples for controversial toxicity from inspiring English sources

On the other hand, histological evaluation of the effect caused by the obtained nanoparticles on the lungs of male Brown Norway rats after a single intratracheal instillation of a solution containing various concentrations of IOSi-NPs was performed in order to clarify the controversial toxicity of these nanoparticles.

With the current exception of the stress-inducible kinase JNK whose excessive activation has been well documented in neurodegenerative diseases [13] and reviewed in [14], the mechanistic relationship between the stress inducible host signaling pathways and expanded polyglutamine-induced toxicity remain controversial.

The link between this MTHFR polymorphism and toxicity remains controversial.

The use of steroids in the setting of SSZ toxicity is controversial and not always effective.

Mitochondrial involvement in IONPs toxicity remains controversial and either no deleterious effects [ 13, 14] or mitochondrial impairments have been observed [ 15– 17].

Thus the role of inflammasome activation in APAP toxicity is controversial and may be dependent on the precise experimental conditions or strain of mice employed.

The role of infiltrating macrophages in liver toxicity is controversial, largely due to the heterogeneity and plasticity of macrophages and difficulties in establishing effective markers to identify and study different populations of macrophages in the liver.

Even though the exact role of aggregates and their involvement in cell toxicity remain controversial [ 42], we observed that the lower number of aggregates is correlated with a recovery of different phenotypes, such as motor performances for instance.

Currently, the American Heart Association recommends use of epinephrine during CPR [ 13], as a first-line drug for treating cardiac arrest, however, the use of epinephrine for bupivacaine-induced cardiac toxicity remains controversial [ 1- 4].

The human health effects of the paraben exposure at environmental levels are still unknown and their toxicity remains controversial since several studies did not achieve to demonstrate the endocrine disruptor effects [ 15, 24, 25].

However, due to ethical reasons, the animal experiments on rodent acute toxicity are highly controversial.